Description
Description: CMPK1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids (1-228) and having a molecular mass of 28kDa. CMPK1 is fused to a 20 a.a His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction: UMP-CMP kinase and deoxycytidylate kinase (CMPK1) is an enzyme which catalyzes the phosphoryl transfer from ATP to UMP, CMP and dCMP. This enzymatic reaction brings about the formation of ADP and the corresponding nucleoside diphosphate that are necessary for cellular nucleic acid synthesis. In addition, CMPK1 has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs